Semi-finalists have been announced in the second annual Sanofi-Aventis DataDesignDiabetes Challenge, the digital health developer challenge with the largest rewards by far.

Each of the five semi-finalists receive $20,000 and have a chance to participate in an intensive mentorship program led by the StartUp America Partnership.

Each team will also partake in a design and prototyping boot camp hosted by sanofi-aventis in San Francisco before making their final pitch to the distinguished panel of judges at Demo Day in NYC on May 16.

The five semi-finalists are spread across the country and each bring very different offerings to the competition. Here is a brief introduction to each:

Diabetes 3.0 helps patients and providers wirelessly collect, aggregate, store, analyze, and display a comprehensive set of diabetes-related data and in real-time from various device sources with the goal of achieving better control of patients’ blood sugars. The team lead is Aaron Neinstein and is based in San Francisco.

LiveHealth is a web-based real-time video platform for patients to visit with a registered dietitian, registered nurse, and a diabetes educator, either individually or in small groups to reduce ER visits, improve lifestyle changes, improve glucose levels, address weight management and improve quality of life. LiveHealth is based in Chicago and is under the direction of Chris Gray.

Activity-based integrated data model is a dynamic database and feedback system that integrates activity that affects blood glucose utilizing the single best measure of activity, the heart rate, to improve blood glucose control. Jim Stritzinger leads the team based in Columbia, SC.

iRetainRx is an interactive mobile system that monitors and enables patients, caregivers, and pharmacists to collaborate and successfully implement treatment action plans. David Parpart leads the team from Sunnyvale, CA.

n4a Diabetes Care Center uses predictive analysis to isolate and target patients based on cost patterns and risk profile to provide them with support and services to slow the progression of the disease, improve the quality of life, and slow the spending associated with the patient’s health. Sandra Markwood is leading the Washington, DC-based team.

These five teams have some large shoes to fill if they want to live up to the winners of the inaugural 2011 DDDiabetes Challenge, ginger.io. The MIT Media Lab spinoff co-founded by Anmol Madan and Karan Singh has followed up their victory with an even more impressive showing as the winners of the SXSW Accelerator, arguably the startup challenge with the biggest rewards from winning teams.

Anmol Madan told BostInno the DDDiabetes Challenge experience was “sort of like the mini TechStars [and] the mini YCombinator of the healthcare space. There’s a financial part of it, but the other big piece of that process is also the introductions, the mentorship, and the patient experience.”

I have repeatedly referred to ginger.io as the most innovative company in mobile health and it seems every few months the company does something impressive to make me look smart. I will certainly be keeping a close eye on the DDDiabetes Challenge to see if this year’s winner has what it takes to be the next ginger.io.